Original paper Administration of leukemia inhibitory factor increases Opalin and myelin oligodendrocyte glycoprotein expression in the cerebral cortex in a cuprizone-induced model of demyelination
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چکیده
منابع مشابه
Administration of leukemia inhibitory factor increases Opalin and myelin oligodendrocyte glycoprotein expression in the cerebral cortex in a cuprizone-induced model of demyelination.
Multiple sclerosis (MS) lesions are characterized by inflammatory demyelination and reactive gliosis, and although remyelination occurs in some lesions it is limited and incomplete. Leukemia inhibitory factor (LIF) is an important cytokine that stimulates oligodendrocyte proliferation and survival in vitro. Opalin is a unique molecular marker for mature oligodendrocytes. The aim of this study w...
متن کاملAdministration of Leukemia Inhibitory Factor Increases Opalin Expression in the Cerebral Cortex of Male Balb/C Mice An In Vivo Study
Background: Leukemia inhibitory factor (LIF) is a neurortophic cytokine which plays an important role in the neural cell survival. Expression of LIF and its receptor, LIFR, in different brain regions has been demonstrated. Based on evidences LIF plays an important role in the modulation of neurogenesis and glial responses to injury. Up-regulation of LIF after central nervous system (CNS) damage...
متن کاملadministration of leukemia inhibitory factor increases opalin expression in the cerebral cortex of male balb/c mice an in vivo study
background: leukemia inhibitory factor (lif) is a neurortophic cytokine which plays an important role in the neural cell survival. expression of lif and its receptor, lifr, in different brain regions has been demonstrated. based on evidences lif plays an important role in the modulation of neurogenesis and glial responses to injury. up-regulation of lif after central nervous system (cns) damage...
متن کاملEffects of Green Tea Epigallocatechin-3-Gallate (EGCG) On Proteolipid Protein (PLP) and Oligodendrocyte Transcription Factor 1 (Olig1) Expression in the Cerebral Cortex of Cuprizone Induced Multiple Sclerosis Mice; A Western Blot Study
Background: The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system. It has been shown that green tea epigallocatechin-3-gallate (EGCG) might be effective in improving the symptoms and pathological conditions associated with autoimmune inflammatory diseases in several animal models. Object...
متن کاملاثر فاکتور مهار کننده لوکمیا بر بیان پروتئین اصلی میلین، Olig1 و Olig2 در کورتکس مغز موش‌های مبتلا به مالتیپل اسکلروزیس القا شده با Cuprizone
Background and purpose: Oligodendrocytes are responsible for myelin synthesis in the central nervous system (CNS). Olig1 and Olig2 play an important role in regulating the development of oligodendrocyte precursor cells (OLPs). Myelin basic protein (MBP) is the main component of myelin sheath. Leukemia inhibitory factor (LIF) has an important role in myelination and pathology of multiple scleros...
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ژورنال
عنوان ژورنال: Folia Neuropathologica
سال: 2015
ISSN: 1641-4640
DOI: 10.5114/fn.2015.52411